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KMID : 1234420090370040399
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Korean Journal of Microbiololgy and Biotechnology
2009 Volume.37 No. 4 p.399 ~ p.404
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Preparation of Functional Cosmetics Containing β-carotene Derived from Recombinant Escherichia coli and Evaluation of Anti-wrinkle Efficacy by Clinical Testing.
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Kim Yoo-Keun
Lee Young-Hoon
Kang Moon-Kook
Lee Byung-Hak
Yun Jun-Ki
Kim Sung-Bae
Kim Chang-Joon
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Abstract
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This paper described the formulation of functional cosmetics and evaluation of anti-wrinkle efficacy in clinical test. Cosmetics were formulated with highly purified β-carotene obtained from the culture broth of recombinant E.coli cells. Edible oil for solubilizing β-carotene, vitamine E for long-term storage, detergent/stabilizer (2.0%) for the complete formation of oil/water emulsion, dimethicone (0.35%) for good skin care, and sorbitol for skin moisturizer were also added as ingredients. Physical or chemical degradation of formulated products stored at 0oC, 25oC, or 40oC was not observed for 60-day testing period. In clinical test, 68% of applicants observed wrinkle decrease after 8-week treatment. This result indicates that newly formulated cosmetics have strong potential for improving wrinkle skin care.
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KEYWORD
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Recombinant Escherichia coli, β-carotene, functional cosmetics, formulation, clinical test
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